Exploring Specialized Pro-Resolving Mediators (SPMS) as Promising Therapeutic Agents for COVID-19

Interestingly, dexamethasone, the first drug approved to treat COVID-19, seems to boost these protective molecules in these patients.

When these protective molecules (called SPMs) were added to white blood cells in the lab, it improved their job of fighting off infections and reduced the activity of molecules that promote inflammation.

Understanding these processes better could help us develop new treatments to make COVID-19 less severe.

Basically, this study gives us a new understanding of what’s going wrong in the bodies of severely ill COVID-19 patients.

It suggests that drugs like dexamethasone, which increase the production of these protective molecules, could be really helpful in calming down inflammation in these patients.

This study found something new about how COVID-19 affects our immune system and how certain substances called SPMs might help. Previous research showed that SPMs can help control inflammation caused by viruses and bacteria. These findings suggest that using SPMs or treatments based on them could be helpful in fighting infections by reducing inflammation without weakening the immune system’s ability to fight off the virus or bacteria.

Reference

Duco Steven Koenis, Issa Beegun, Charlotte Jouvene, Gabriel Amador Aguirre, Patricia R Souza, Maria Gonzalez-Nunez, Lucy Ly, Kimberly Pistorius, Hemant M Kocher, William Ricketts, Gavin Thomas, Mauro Perretti, Ghassan Alusi, Paul Pfeffer, Jesmond Dalli. Disrupted Resolution Mechanisms Favor Altered Phagocyte Responses in Covid-19. Circulation Research, 2021; DOI: 10.1161/CIRCRESAHA.121.319142

Disclaimer:

Dr. Berner does not diagnose, treat, or prevent any medical diseases or conditions; instead, he analyzes and corrects the structure of his patients with Foundational Corrections to improve their overall quality of life. He works with their physicians, who regulate their medications. This blog post is not designed to provide medical advice, professional diagnosis, opinion, treatment, or services to you or any other individual. The information provided in this post or through linkages to other sites is not a substitute for medical or professional care. You should not use the information in place of a visit, consultation, or the advice of your physician or another healthcare provider. Foundation Chiropractic and Dr. Brett Berner are not liable or responsible for any advice, the course of treatment, diagnosis, or any other information, services, or products you obtain through this article or others.